An intramolecular Diels-Alder approach to the eunicellins: enantioselective total syntheses of ophirin B and astrogorgin.
نویسندگان
چکیده
The enantioselective syntheses of the eunicellins ophirin B and astrogorgin have been completed. Ring-closing metatheses provide efficient access to the oxonene rings, and highly diastereoselective intramolecular Diels-Alder reactions resulted in the formation of the hydrobenzofuran portion of the molecules.
منابع مشابه
An intramolecular Diels-Alder strategy for the asbestinins: enantioselective total syntheses of 11-acetoxy-4-deoxyasbestinin D and asbestinin-12.
The enantioselective total syntheses of 11-acetoxy-4-deoxyasbestinin D and asbestinin-12 have been completed. A glycolate aldol reaction provided a diene useful for ring-closing metathesis to form an oxonene, which was ultimately employed as a template to execute a highly stereoselective intramolecular Diels-Alder cycloaddition, forming the hydroisobenzofuran moiety. The absolute configuration ...
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ورودعنوان ژورنال:
- Journal of the American Chemical Society
دوره 128 4 شماره
صفحات -
تاریخ انتشار 2006